Adjuvant? Neoadjuvant? Short course? Long course? The treatment of rectal cancer treatment has come a long way. Tune in to learn more about Total Neoadjuvant Therapy (TNT) and the mysterious HOLY PLANE.
Learning Objectives: 1. Describe the rationale for Total Neoadjuvant Therapy (TNT) for rectal cancer 2. Review the history of chemo and radiation therapy in treatment of rectal cancer 3. Describe total mesorectal excision References Bahadoer RR, Dijkstra EA, van Etten B et al. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2021 Jan;22(1):29-42. doi: 10.1016/S1470-2045(20)30555-6. Epub 2020 Dec 7 https://doi.org/10.1016/S1470-2045(20)30555-6 Fokas E, Allgäuer M, Polat B et al. Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12. J Clin Oncol. 2019 Dec 1;37(34):3212-3222. doi: 10.1200/JCO.19.00308 https://ascopubs.org/doi/10.1200/JCO.19.00308 Colorectal Surgery 2021-2022 Virtual Education Series Follow us on Twitter @CRSVirtualEd Email us: colorectal.educational.series@gmail.com www.crsvirtualed.org Please visit behindtheknife.org to access other high-yield surgical education podcasts, videos and more.